Subgroup | miRNA | C-index (95% CI) | Improvement in c-index | Reclassification indexes at 2 years | |||||
---|---|---|---|---|---|---|---|---|---|
Clinical model 1 | Clinical model 1 + miRNA | Δc-index (95% CI) | p-value | cNRI (95% CI) | p-value | IDI (95% CI) | p-value | ||
Model 1 | miR-133a-3p | 0.568 (0.534–0.602) | 0.597 (0.562–0.631) | 0.029 (0.005; 0.052) | 0.016 | 0.277 (0.036; 0.436) | 0.014 | 0.020 (0.004; 0.044) | 0.002 |
miR-501-3p | 0.574 (0.539–0.609) | 0.577 (0.542–0.612) | 0.003 (− 0.002; 0.007) | 0.21 | 0.085 (− 0.136; 0.246) | 0.42 | 0.001 (− 0.001; 0.010) | 0.37 | |
Model 2 | miR-133a-3p | 0.678 (0.647—0.709) | 0.685 (0.654—0.716) | 0.007 (− 0.003; 0.016) | 0.17 | 0.230 (0.022; 0.416) | 0.024 | 0.015 (0.001; 0.037) | 0.016 |
miR-501-3p | 0.682 (0.650–0.714) | 0.686 (0.653–0.718) | 0.004 (− 0.003; 0.011) | 0.29 | 0.079 (− 0.100; 0.291) | 0.23 | 0.008 (− 0.000; 0.025) | 0.086 | |
Model 3 | miR-133a-3p | 0.731 (0.703–0.759) | 0.734 (0.706–0.761) | 0.003 (− 0.002; 0.007) | 0.25 | 0.162 (− 0.195; 0.345) | 0.25 | 0.003 (− 0.002; 0.015) | 0.33 |
miR-501-3p | 0.736 (0.708–0.765) | 0.737 (0.708–0.766) | 0.001 (− 0.002; 0.003) | 0.52 | 0.089 (− 0.265; 0.304) | 0.39 | 0.001 (− 0.001; 0.009) | 0.37 |