Fig. 5

Evaluation of expression profile in PDOs derived from Galc carriers with PDAC. a Volcano plot depicting the differentially expressed genes between Galc carrier PDAC PDOs (n = 2) and non-carrier PDAC PDOs (n = 27). Dashed vertical lines represent the threshold of log2 fold-change (range of ≥ 1 and ≤  − 1) and the horizontal line represents the threshold of statistical significance (adjusted P ≤ 0.05). The colors indicate whether the differentially expressed genes were significantly down-regulated (log2 fold-change ≤  − 1; blue), or up-regulated (log2 fold-change ≥ 1; red). b and c Biological process, cellular components and molecular function were identified from the GO and KEGG enrichment analyses. GO gene ontology, KEGG Kyoto encyclopedia of genes and genomes