Fig. 6
Evaluation of disease markers in Lmna DCM. (a and c) Heat map representing color-coded log2 fold change of the gene expression of Nppa, Nppb, Myh7, Col1a1 and Col1a2, immunostaining (αSMA, Iba1, CD3, γH2AX, Ki67), Western blot (p-Smad2) and histology (fibrosis). (a) EF or (c) survival of Lmna DCM mice supplemented with selected candidates or control, n = 5. (b and d) Hierarchical clustering and correlation analysis of log2 fold change of selected markers with (b) EF or (d) survival of Lmna DCM mice supplemented with selected candidates or control by nonparametric Spearman correlation, n = 5