Fig. 2

RNAseq analysis of Lmna DCM with Lamin A or Lamin C upregulation. (a and b) Heat map representing color-coded expression level of genes that are significantly changed in Lmna DCM mice supplemented with (a) Lamin C or (b) Lamin A. Venn diagram of overlap between upregulated (red) and downregulated (green) genes in Lmna DCM with (a) Lamin C or (b) Lamin A upregulation compared to Lmna DCM mice. Mice were harvested four weeks after transduction, n = 3. (c) Venn diagram of overlap between Lmna DCM upregulated genes in Lamin A or Lamin C treatment. (d) Hallmark signature depicting top 10 dysregulated pathways of upregulated differentially expressed genes (DEGs) which cannot be reversed by Lamin A as designated by GSEA, arranged by NES