Fig. 1

Effect of Lamin A and Lamin C on Lmna DCM in mice. (a and d) Experimental timeline showing timepoints of virus injection and echocardiogram. Sirius Red (SR) and H&E staining of paraffin heart sections and quantifications of Lmna DCM mice supplemented with control, Lamin A or Lamin C. Quantification of myocardial fibrosis of SR sections, n = 5, Brown-Forsythe and Welch ANOVA test with Dunnett’s T3 correction. For complete heart images: magnification = 4 × , scale bar = 1000 µm; for enlarged images: magnification = 20 × , scale bar = 100 µm. (b and e) Quantitative real-time PCR analyses of Nppa, Nppb, Col1a1 and Col1a2 in Lmna DCM mice supplemented with control, Lamin A or Lamin C, n = 5, Brown-Forsythe and Welch ANOVA test with Dunnett’s T3 correction. (c and f) Survival curve of Lmna DCM mice supplemented with Lamin A (Red) or Lamin C (Red) compared to Lmna DCM mice (Black) and Ctrl (Blue), n = 10, Log- rank (Mantel- Cox) test