Fig. 8

Synovium facilitates the conversion of iron from a systemic distribution to a localized distribution. A Prussian Blue staining of the synovium. B Serum levels of ferritin and Fe²⁺. C Ferritin and Fe²⁺ levels in the synovium. D Univariate linear regression analysis between ferritin levels in serum and synovium. E Univariate linear regression analysis between Fe²⁺ levels in serum and synovium. F Activity of SOD. G Activity of LDH. SOD, superoxide dismutase; LDH, lactate dehydrogenase; ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 versus K–L Grade 2; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus K–L Grade 3