Fig. 3

Identification of JUN and ZFP36 as potential target genes in the development of OA-associated synovitis. A Protein–protein interaction network of the hub genes. Red represents upregulation and blue represents downregulation. B Venn diagram for screening JUN and ZFP36. C Distribution of JUN and ZFP36 expression in the internal datasets. D Diagnostic ROC curves of JUN and ZFP36 for OA-associated synovitis. E GSEA analysis of JUN and ZFP36. DEGs, differentially expressed genes; ROC, receiver operating characteristic; GSEA, gene set enrichment analysis; ^**P < 0.01, ^***P < 0.001 versus the control group