Skip to main content

Table 1 Viral payload of hDPSC after infection with YSCH-01

From: Potent antitumor efficacy of human dental pulp stem cells armed with YSCH-01 oncolytic adenovirus

Experiments

Virus initial infectious dose (VP/cell)

Intracellular viral payload(ifu/cell)

The % index (ifu/VP)

Intracellular VP per cell

Injected cells (YSCH-01/hDPSCs) number in vivo

The amounts of virus delivered by hDPSCs in vivo

EXP 1

1000

5.13 × 10–3

0.884

0.58

2 × 106

1.16 × 106

EXP 2

1000

8.43 × 10–3

0.878

0.96

2 × 106

1.96 × 106

Average

1000

6.78 × 10–3

/

0.77

2 × 106

1.54 × 106

  1. Cellular viral payload of YSCH-01/hDPSCs. The human dental pulp cells were infected with YSCH-01 at a dosage of 1000 VP/cell for 4 h, then washed 3 times with 1 × PBS buffer. After that, the infected hDPSCs were used for detection of the intracellular virus payload by virus titer assay as well as observation of the antitumor efficacy in xenograft mice models through IP injection. Ifu: infectious unit, VP: virus particles.
Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us