A novel deep learning-based algorithm combining histopathological features with tissue areas to predict colorectal cancer survival from whole-slide images

Table 2 Details of the tissue area features

Tissue area feature	Definition	Cutoff point^a	p value**
max_tumor_area	The area of max tumor	11,854	0.0029
lymphocyte_inside_tumor	The area of lymphocytes inside tumors	245	0.081
lymphocyte_around_tumor	The area of lymphocytes around tumors	388	0.045
around_inside_ratio	lymphocyte_around_tumor + 1/lymphocyte_inside_tumor + 1	0.8581315	< 0.0001
total_stroma_area	The area of total stroma	7324	0.014

^aThe cutoff point is determined by the maximally selected rank statistics method
^** p value is determined by the log-rank test

ISSN: 1479-5876