Fig. 6

MMP7 is upregulated in CRC and associated with a poor prognosis. A, B Expression level of MMP7 in unpaired tumor tissues and normal tissues of TCGA-COAD (Normal, n = 41; Tumor, n = 480, Welch t’ test), or READ (Normal, n = 10; Tumor, n = 167, Welch t’ test). C, D Expression level of MMP7 in paired tumor tissues and adjacent normal tissues of TCGA-COAD (Normal, n = 41; Tumor, n = 41; Wilcoxon signed rank test) or READ (Normal, n = 9; Tumor, n = 9, Paired t test). E, F Pearson correlation between the MAPK signaling pathway and the expression of MMP7 in the tumor tissues from TCGA-COAD/READ (COAD, n = 471, READ, n = 165). G Pearson correlation between the expression of JUN and MMP7 in the tumor tissues from TCGA-COAD (n = 480). (H, I) Kaplan–Meier survival curves were analyzed and compared between patients with low and high level of JUN (H) and MMP7 (I) in CRC patients from the GEO combined dataset (n = 864, the log-rank test). J, K The JUN (J) and MMP7 (K) expression score of CMS1/2/3 (n = 713) or CMS4 (n = 340, Wilcoxon signed rank test) group in the GEO combined dataset. Data are shown as mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001