Fig. 1

 F. nucleatum infection affects gene expression profile and biological function of colorectal cancer cell. A–D Volcano plots (A, B) and Heat maps (C, D) representing the differentially expressed genes between F. nucleatum-infected and PBS-treated colorectal cancer cells (GSE173549, LoVo; GSE102573, Caco-2). E Protein−protein interaction network of genes upregulated in both two cell lines. Network nodes represent proteins, and Edges represent protein−protein associations. F The top upregulated and downregulated genes by F. nucleatum infection via RRA analysis. G, H The activated pathways by F. nucleatum infection via KEGG enrichment analysis. I, J The biological functions influenced by F. nucleatum infection via GO enrichment analysis. K, L The hallmarks of CRC cell affected by F. nucleatum infection via GSVA