Fig. 5
From: Characterization of novel CD19-specific VHHs isolated from a camelid immune library by phage display
The 2D interaction plots of GR37 and GR41 as docked to CD19 and the predicted impact of temperature on their affinity to CD19. a and b: The 2D interaction plots of GR37 and GR41 as docked to CD19, respectively. The horizontal dashed line shows the interface between the VHH and the antigen. The interactive CD19 and VHH residues are represented above and below the dashed line, respectively. Hydrophobic contacts are indicated by arcs whose radiating spokes are directed toward the atoms they are in contact with. Also, dashed lines between atoms are representatives of hydrogen bonds. The VHH residues are presented with the “V” chain whereas CD19 is in the “A” chain. All antibody residue numberings are in accordance with the Kabat numbering scheme. c: The predicted impact of temperature on the predicted affinity of GR37 and GR41 to CD19