Fig. 4

The amino acid sequences of GR37 and GR41, their predicted 3D structures, and the ClusPro results of their docking to CD19. a and b: The amino acid sequences of GR37 and GR41, respectively. c and d: The cartoon presentation of the most favorable predicted 3D model of GR37 and GR41 as modeled by the Robetta server structurally aligned with their corresponding counterparts modeled by the NanoBodyBuilder2 server, respectively. For the models predicted by the Robetta server, the framework regions are in red whereas the complementarity-determining regions (CDRs) are presented in gray. For the models predicted by the NanoBodyBuilder2 server, the framework regions are in light blue whereas the CDRs are yellow. e and f: The ClusPro results of the docking of GR37 and GR41 to CD19 in cartoon representation, respectively. The frameworks are shown in red, CDRs in grey, and CD19 in pale yellow. g and h: The ClusPro results of the docking of GR37 and GR41 to CD19 in surface model, respectively. The frameworks are shown in red, CDRs in grey, and CD19 in pale yellow