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Table 3 Comparison of risk predicted from established models among Chinese patients with ultra-high, high, low and ultra-low risk based on quartile risk classification of 70-gene signature test

From: Nomogram prediction of the 70-gene signature (MammaPrint) binary and quartile categorized risk using medical history, imaging features and clinicopathological data among Chinese breast cancer patients

Risk calculated from established models

70-gene ultrahigh risk N = 12 (%) 4

70-gene high risk N = 50 (%) 3

70-gene low risk N = 65 (%) 2

70-gene ultralow risk N = 23 (%) 1

P-value

AOL

    

0.861&

 High (1)

9 (75.0)

37 (74.0)

44 (67.7)

17 (73.9)

 

 Low (0)

3 (25.0)

13 (26.0)

21 (32.3)

6 (26.1)

 

CTS5

    

0.162

 Score (Mean ± SD)

3.34 ± 0.41

3.28 ± 0.62

3.14 ± 0.63

3.13 ± 0.66

 

CTS5

    

0.250^

 High (2)

1 (8.3)

7 (14.0)

9 (13.8)

3 (13.0)

 

 Intermediate (1)

8 (66.7)

25 (50.0)

22 (33.8)

7 (30.4)

 

 Low (0)

3 (25.0)

18 (36.0)

34 (52.3)

13 (56.5)

 

IHC3

    

 < 0.001^

 High (1)

10 (83.3)

17 (34.0)

10 (15.4)

0 (0.0)

 

 Low (0)

2 (16.7)

33 (66.0)

55 (84.6)

23 (100.0)

 

NPI

    

 < 0.001

 Score (Mean ± SD)

4.83 ± 0.58

4.52 ± 0.45

4.34 ± 0.46

4.18 ± 0.65

 

NPI

    

0.768^

 Poor (2)

0 (0.0)

1 (1.5)

0 (0.0)

0 (0.0)

 

 Moderate (1)

9 (75.0)

39 (78.0)

43 (66.2)

17 (73.9)

 

 Good (0)

3 (25.0)

11 (22.0)

21 (32.3)

6 (26.1)

 
  1. AOL Adjuvant! Online, CTS5 Clinical treatment Score post–5 years; IHC3 immunohistochemistry 3, NPI Nottingham prognostic index
  2. &The comparison was performed by Chi square test of continuous correction
  3. ^The comparison was performed by fisher test