Fig. 5
From: Tyrosine kinase signaling-independent MET-targeting with CAR-T cells
MET-CAR-T cell efficacy against MHCC97H orthotopic tumor growth in nude mice. A Time line of orthotopic tumor initiation and MET-CAR-T cell injection (i.v.). B MHCC97H orthotopic tumor growth measured by BLI. C Tumor growth curve plotted with BLI signal intensity of individual mice as shown in B. Darker line indicates the average signal intensity of each group. Bar with brackets refers to standard deviation. Note that at Day 19, BLI signal intensity in MET-CAR.CD28ζ and MET-CAR.4-1BBζ groups are significantly lower than that in MET-CAR∆ group (student t test, one tail, * p < 0.05; ** p < 0.01). D PD-1 expression level in NT and MET-CAR-T cells after 3-day co-culture with MHCC97H cells analyzed by flow cytometry. E Averaged results of PD-1 expression in MET-CAR-T cells from HS (n = 6) and HCC cases (n = 5). Short bar refers to standard deviation. (*paired t test, p < 0.01; **student t test, p < 0.01)