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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Characterization of tumor microenvironment and tumor immunology based on the double-stranded RNA-binding protein related genes in cervical cancer

Fig. 3

Relationship between dsRBP clusters and TME. A Comparison of cancer immune cycle steps between cluster 1/2 and 3 (cluster 1/2, n = 234; cluster 3, n = 70). B The stromal score, immune score, and ESTIMATE score of cluster 1/2 and 3. Differences in TIICs enrichment applied by XCELL (C) and CIBERSORT (D) between distinct clusters. E Hub genes involved in the three characteristics were compared across clusters by heat map. The expression levels of 48 immune checkpoints (F) and HLA family genes (G) between cluster 1/2 and 3. The ssGSEA value (H) and immunogram radar plot (I) revealed the relationship between distinct clusters and TME signatures generated by Kobayash. The ssGSEA value (J) and immunogram radar plot (K) revealed the relationship between distinct clusters and TME signatures generated by Bagaev. TME tumor microenvironment, TIICs tumor infiltrating immune cells, HLA human leukocyte antigen. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns: nonsignificant

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Journal of Translational Medicine

ISSN: 1479-5876

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