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Table 2 Weighted linear regression showing the relationship between LE8/CVH and biological ageing

From: Association between life’s essential 8 and biological ageing among US adults

 

Crude model

Model 1

Model 2

β (95%CI)

P

β (95%CI)

P

β (95%CI)

P

 

Phenotypic age

LE8

 − 0.450 (− 0.487, − 0.413)

 < 0.0001

 − 0.170 (− 0.181, − 0.158)

 < 0.0001

 − 0.129 (− 0.142, − 0.117)

 < 0.0001

CVH

 Low

ref

 

ref

 

ref

 

 Moderate

 − 10.505 (− 11.744, − 9.267)

 < 0.0001

 − 4.730 (− 5.325, − 4.135)

 < 0.0001

 − 3.047 (− 3.596, − 2.498)

 < 0.0001

 High

 − 20.118 (− 21.734, − 18.502)

 < 0.0001

 − 7.406 (− 7.953, − 6.858)

 < 0.0001

 − 5.268 (− 5.831, − 4.705)

 < 0.0001

P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

 

Biological age

LE8

 − 0.435 (− 0.465, − 0.405)

 < 0.0001

 − 0.187 (− 0.197, − 0.177)

 < 0.0001

 − 0.117 (− 0.127, − 0.107)

 < 0.0001

CVH

 Low

ref

 

ref

 

ref

 

 Moderate

 − 9.966 (− 11.172, − 8.760)

 < 0.0001

 − 5.101 (− 5.628, − 4.573)

 < 0.0001

 − 2.94 (− 3.381, − 2.498)

 < 0.0001

 High

 − 19.347 (− 20.765, − 17.930)

 < 0.0001

 − 8.098 (− 8.697, − 7.498)

 < 0.0001

 − 4.76 (− 5.303, − 4.217)

 < 0.0001

P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

 

PhenoAgeAccel

LE8

 − 0.193 (− 0.204, − 0.182)

 < 0.0001

 − 0.170 (− 0.181, − 0.158)

 < 0.0001

 − 0.129 (− 0.142, − 0.117)

 < 0.0001

CVH

 Low

ref

 

ref

 

ref

 

 Moderate

 − 5.413 (− 6.007, − 4.819)

 < 0.0001

 − 4.73 (− 5.325, − 4.135)

 < 0.0001

 − 3.047 (− 3.596, − 2.498)

 < 0.0001

 High

 − 8.788 (− 9.312, − 8.264)

 < 0.0001

 − 7.406 (− 7.953, − 6.858)

 < 0.0001

 − 5.268 (− 5.831, − 4.705)

 < 0.0001

P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

 

BioAgeAccel

LE8

 − 0.178 (− 0.189, − 0.166)

 < 0.0001

 − 0.187 (− 0.197, − 0.177)

 < 0.0001

 − 0.117 (− 0.127, − 0.107)

 < 0.0001

CVH

 Low

ref

 

ref

 

ref

 

 Moderate

 − 4.874 (− 5.429, − 4.320)

 < 0.0001

 − 5.101 (− 5.628, − 4.573)

 < 0.0001

 − 2.94 (− 3.381, − 2.498)

 < 0.0001

 High

 − 8.017 (− 8.655, − 7.379)

 < 0.0001

 − 8.098 (− 8.697, − 7.498)

 < 0.0001

 − 4.76 (− 5.303, − 4.217)

 < 0.0001

P for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

  1. Crudel model: unadjusted model;
  2. Model 1: Adjusted for age, sex, race, marital status, education, poverty-income ratio, and alcohol using;
  3. Model 2: Additionally adjusted for hypertension, CVD, diabetes, and cancer
  4. LE8, life’s essential 8; CVH, cardiovascular health; PhenoAgeAccel, phenotypic age acceleration; BioAgeAccel, biological age acceleration
  5. Low CVH was defined as a LE8 score of 0 to 49, moderate CVH of 50–79, and high CVH of 80–100
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Journal of Translational Medicine

ISSN: 1479-5876

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