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Table 1 Univariate and Multivariate analysis of Siglec-15 and clinicopathological factors in LUAD in TMUCIH cohort

From: Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas

Variables

Univariate analysis

Multivariate analysis

S15 in TC

S15 in MC

n

P

HR (95%CI)

P

HR (95%CI)

P

Gender

 Females

114

0.339

–

–

–

–

 Males

82

Age (years)

 ≥ 60

92

0.568

–

–

–

–

 < 60

104

Smoking

 Yes

69

0.686

–

–

–

–

 No

127

T classification

 T2–4

94

< 0.001

1.577 (1.057–2.354)

0.026

1.570 (1.052–2.342)

0.027

 T1

102

N classification

 N1–2

72

< 0.001

2.179 (1.452–3.271)

< 0.001

2.163 (1.445–3.238)

< 0.001

 N0

124

S15 in the TC

 High

30

0.032

1.389 (0.857–2.252)

0.183

  

 Low

166

S15 in the MC

 High

144

0.008

  

1.497 (1.006–2.228)

0.047

 Low

52

  1. Statistically significant differences (P < 0.05) are bolded
  2. Multivariate analysis was performed by the Cox multivariate proportional hazard regression model with stepwise manner
  3. TNM Tumor-nodes-metastases, HR Hazard ratio, CI Confidential interval, S15 Siglec-15 
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Journal of Translational Medicine

ISSN: 1479-5876

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