Fig. 7

Tumor microenvironment immune type (TMIT) based on Siglec-15 and CD8A/CD8⁺ T cells. A Siglec-15 were weakly positively correlated with immune response-related biomarkers and signatures. B S15^H was accompanied by IFN-γ, (C) and TGF-β response activation. D Representative mfIHC images showed immunotyping based on Siglec-15 expression and CD8⁺ T cells in the TC, (H) and MC. E Siglec15 expression proportion in the four TMIT in the TC, (I) and MC. F The proportion of patients with S15^H was higher in the CD8^H group in the TC, (J) and MC. G Patients with CD8^L + S15^H group had the worst DFS prognosis in the TC, (K) and MC. L In the case of low CD8⁺ T cell infiltration, the CD68⁺ TAMs density tended to be increased in the S15^H group compared with the S15^L group in the TC, (M) and MC. N Patients with CD8A^H + S15^H exhibited the activation of immune-related hallmark markers. O Patients with CD8A^L + S15^H showed the activation of metabolism-related hallmark markers