Fig. 1

Expression signature of Siglec-15 in the tumor and macrophage compartment in LUAD in TMUCIH cohort (n = 213). A Representative mfIHC images displayed Siglec-15 expression in LUAD. Scale bar, 5 μm. B Positivity rate for Siglec-15 expression was 46% in the TC, 74% in the MC, and 50% in the SC, at a cut-off value of 1%. C Siglec-15 expression was higher in CK⁺ cells and CD68⁺ cells than that in the CK⁻CD68⁻ cells. D 28.2% of patients with LUAD displayed S15^H. E Siglec15 expression proportion in tumor and macrophage. F Representative mfIHC images showed Siglec-15 was predominantly expressed in CD163⁺ M2-like TAMs. Scale bar, 50 μm. G Siglec-15 was predominantly expressed in M2-like TAMs