Fig. 3

ROC curve analysis of CSF NGAL and serum NGAL for the diagnosis of acute bacterial meningitis. A, ROC curve of CSF NGAL for discriminating patients with BM (n = 67) from HC (n = 58) with an AUC of 0.955 (0.903–0.984; P < 0.001). B, ROC curve of CSF NGAL for discriminating patients with BM (n = 67) from TBM (n = 55) with an AUC of 0.805 (0.723–0.871; P < 0.01). C, ROC curve of CSF NGAL for discriminating patients with BM (n = 67) from CM (n = 51) with an AUC of 0.865 (0.790–0.921; P < 0.01). D, ROC curve of CSF NGAL for discriminating patients with BM (n = 67) from TBM (n = 55) and CM (n = 51) with an AUC of 0.834 (0.770–0.886; P < 0.01). E, ROC curve of serum NGAL for discriminating patients with BM (n = 67) from TBM (n = 55) with an AUC of 0.576 (0.483–0.665; P > 0.05). F, ROC curve of serum NGAL for discriminating patients with BM (n = 67) from CM (n = 51) with an AUC of 0.674 (0.554–0.733; P = 0.035). G, The ability of CSF NGAL and traditional CSF assays (CSF WBC, chloride, glucose, and protein) to differentiate between patients with BM (n = 67) and HC (n = 58) was evaluated using ROC curve analysis. H, The ability of CSF NGAL and traditional CSF assays (CSF WBC, chloride, glucose, and protein) to discriminate patients with BM (n = 67) from TBM (n = 55) and CM (n = 51) was evaluated using ROC curve analysis. NGAL Neutrophil Gelatinase-Associated Lipocalin, BM bacterial meningitis, TBM tuberculous meningitis, CM cryptococcal meningitis, HC hospitalized controls, WBC White blood count, CL chloride, GLU glucose, PRO protein. *P < 0.05; **P < 0.01, ***P < 0.001, compared with the BM group