Table 1 Characteristics of the studies and subjects included in the meta-analysis
From: Cell-therapy for Parkinson’s disease: a systematic review and meta-analysis
Study | Patient | Intervention | Follow-up (months) | Outcome | Study type and origin | ||||
|---|---|---|---|---|---|---|---|---|---|
N/male | Age (years) | Disease duration (year) | Cell type | Cell count | Graft location | ||||
Schiess 2021 [102] | 20/11 | 66.4 ± 7.0 | 5.5 ± 1.8 | Allogeneic bone marrow mesenchymal stem cells | 1, 3, 6, or 10 × 106/kg | Intravenous infusion | 3, 6, 12 | (1), (3)-(5), (9), (11) | Prospective, single-center, USA |
Venkataramana 2012 [103] | 8/7 | 54.6 ± 10.0 | 8.3 ± 3.8 | Allogeneic bone marrow mesenchymal stem cells | 2 × 106/kg | Bilateral subventricular zone | 12 | (1), (8), (11) | Prospective, single-center, India |
Boika 2020 [104] | 12/7 | 49.8 ± 12.4 | 5.7 ± 5.5 | Autologous bone marrow mesenchymal stem cells | 0.5–2 × 106/kg 5–12.6 × 106/kg | Intravenous infusion Intravenous + intranasal | 1, 3 | (3), (6), (9) | Prospective, single-center, Belarus |
Storch 2012 [105] | 7/5 | 60.6 ± 12.9 | 10.3 ± 2.9 | Autologous bone marrow mesenchymal stem cells | 2 × 106 | Intrathecal injection + intravenous infusion | 1–15 | (1), (4), (5) | Retrospective, multi-center, German and Italy |
Brazzini 2010 [106] | 53/37 | 61.8 ± 10.7 | 9.1 ± 5.4 | Autologous bone marrow stem cells | NP | Superselective intraarterial (posterior region of the circle of Willis) | 1–18 | (1), (4)-(6), (11) | Retrospective, single-center, USA |
Madrazo 2019 [107] | 7/5 | 54.3 ± 10.9 | 7.7 ± 5.5 | Allogeneic human neural progenitor cells | 2 × 106 | Bilateral dorsal putamina | 12, 24, 48 | (1)-(7), (11)-(13) | Prospective, single-center, Mexico |
Lige 2016 [108] | 21/15 | 57.3 ± 9.1 | NP | Allogeneic human neural precursor cells | 3 × 107 | Unilateral striatum | 7–57 | (1)-(9), (11) | Prospective, single-center, China |
Sinelnyk 2015 [109] | 32/22 | 47.2 ± 6.7 | NP | Allogeneic fetal stem cells | 5.46 × 106 | Vein and anterior abdominal | 6, 12 | (5), (6), (8) | Prospective, single-center, USA |
Yin 2012 [110] | 12/5 | 66.3 ± 11.9 | 6.4 | Allogeneic human retinal pigment epithelial cells | 1 × 106 | Unilateral postcommissural putamen | 3, 6, 12, 24, 36 | (1)-(5), (11), (14) | Prospective, single-center, China |
Gross 2011 [111] | 35/22 | 56.4 ± 7.5 | NP | Allogeneic human retinal pigment epithelial cells | 6.5 × 105 | Bilateral postcommissural putamen | 12, 24, 36, 48 | (2), (3), (5), (9), (11) | RCT, multi-center, USA |
Stover 2005 [112] | 6/3 | 52.2 | 10.2 | Allogeneic human retinal pigment epithelial cells | 3.25 × 105 | Unilateral postcommissural putamen | 3, 6, 12, 18, 24 | (1)-(3), (9), (10) | Prospective, single-center, USA |