Fig. 7
From: Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma
Schematic diagram of PRELP activity in hallmarks of cancer. The reduced PRELP expression in melanoma cells is associated with low expression levels of MHC class I APM components and members of the IFN-γ signal transduction as well as CCL5, which could be reverted by reconstitution of PRELP. PRELP induces the expression of MHC class I and secretion of CCL5 in melanoma cells, which contributes to the recruitment of effector T cells into the tumor tissues and increased recognition by CD8+ T cells (created with BioRender.com)