Fig. 6
From: Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma
Link of CD8+ T cell infiltration levels with PRELP and CCL5 expression in melanoma. A, B Data sets of tumor skin cutaneous melanoma (A) and metastatic melanoma (B) were analyzed by bioinformatics and linked to immune cell infiltration. The prognostic signature of the infiltration of CD8+ T cell subpopulations and the expression of PRELP profiled by xCell algorithm is represented as the Cox model. C A correlation plot was displayed between CCL5 and CD8+ T infiltration in a cohort of 480 melanoma samples of the TCGA dataset. D Secretion of CCL5 in PRELPhigh vs. PRELPlow melanoma cells. Supernatants of PRELPhigh and PRELPlow/negative Buf1088 cells were analyzed for the production of the chemokine CCL5 cells using ELISA as described in “Methods”. Representative data from three independent experiments are shown. The statistical significance is presented as **p < 0.01