Fig. 1
From: Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma
Correlation of PRELP expression in tumors of distinct origin and healthy controls and its clinical relevance. A Reduced PRELP expression in solid tumors compared to normal healthy tissues. PRELP expression was determined in 5.487 normal tissue samples and 35.806 cancer tissues. B Decreased PRELP expression in skin cancer cell lines compared to its normal counterparts. Box plots comparing PRELP expression in skin cancer (247 samples) vs. normal skin cell lines (32 samples) are shown. The data are expressed as log2FC-fold change in a logarithmic scale (base 2). C Distinct PRELP expression patterns in primary and metastatic skin tissues. A box plot comparing PRELP expression between metastases vs. primary tumors is shown. D Increased overall survival of melanoma patients with high PRELP expression levels in tumors. The Kaplan–Meier survival curve of PRELPhigh and PRELPlow melanoma patients from the GEO (ID GSE98394; [68]) melanoma dataset was analyzed and presented as a Kaplan–Meier plot as described in “Methods”. The statistical significance is presented as *p < 0.05; **p < 0.01; ***p < 0.001