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Table 1 Colocalization results of eQTLs for 11 genes with RA-associated SNPs

From: Identification of potential drug targets for rheumatoid arthritis from genetic insights: a Mendelian randomization study

Gene

PP.H0

PP.H1

PP.H2

PP.H3

PP.H4

CCR6

0.000

0.000

0.000

0.000

1.000

HLA-DPA1

0.000

0.000

0.000

0.000

1.000

HLA-DRB1

0.000

0.000

0.000

0.000

1.000

IFNGR2

0.000

0.000

0.000

0.000

1.000

C5

0.000

0.000

0.000

0.000

1.000

ATP2A1

0.000

0.014

0.000

0.000

0.986

FEN1

0.002

0.000

0.013

0.000

0.984

OPRL1

0.000

0.215

0.000

0.000

0.785

FCGR2B

0.000

0.620

0.000

0.338

0.042

ITPR3

0.000

0.000

0.000

1.000

0.000

  1. PP.H0–PP.H4 represent the posterior probabilities of different hypotheses
  2. PP.H4 > 0.8 represents a strong colocalization between gene expression and RA risk