Table 2 Cytokine profile in first-trimester serum
From: Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia
Cytokine (pg/mL) | Control (N = 34) | PE (N = 34) | P value | Cytokine (pg/mL) | Control (N = 34) | PE (N = 34) | P value |
|---|---|---|---|---|---|---|---|
IL-1β | 0.75 (0.59, 1.11) | 0.86 (0.63, 1.50) | 0.253 | G-CSF | 399.98 (126.85, 829.60) | 255.96 (73.95, 645.37) | 0.204 |
IL-1α | 11.94 (10.44, 15.21) | 12.55 (10.14, 15.83) | 0.796 | M-CSF | 1.81 (1.52, 1.94) | 1.81 (1.60, 2.16) | 0.383 |
IL-1ra | 182.92 (164.35, 208.81) | 196.10 (154.56, 262.78) | 0.689 | GM-CSF | 0.83 (0.65, 1.15) | 0.83 (0.65, 1.17) | 0.995 |
IL-2 | 1.77 (1.50, 1.91) | 1.65 (1.53, 2.00) | 0.692 | LIF | 17.93 (14.73, 23.11) | 18.28 (15.45, 25.30) | 0.745 |
*IL-2Rα | 3.5 ± 1.23 | 4.91 ± 3.26 | 0.023 | SCF | 13.54 (7.59, 27.51) | 13.69 (9.56, 20.33) | 0.787 |
IL-3 | 0.72 (0.66, 0.85) | 0.76 (0.66, 0.92) | 0.692 | Eotaxin | 1.85 (1.32, 3.88) | 1.94 (1.14, 4.31) | 0.951 |
IL-4 | 1.45 (1.21, 1.67) | 1.29 (1.13, 1.60) | 0.217 | MIP-1α | 16.84 (4.05, 37.04) | 8.53 (1.86, 40.02) | 0.524 |
IL-5 | 8.37 (7.80, 12.77) | 8.37 (6.10, 11.69) | 0.513 | MIP-1β | 37.09 (25.71, 97.07) | 43.37 (29.90, 96.30) | 0.704 |
IL-6 | 0.68 (0.60, 1.23) | 0.65 (0.60, 0.95) | 0.468 | FGF Basic | 15.45 ± 4.07 | 17.16 ± 4.23 | 0.095 |
IL-7 | 6.63 (6.06, 7.74) | 6.63 (6.06, 7.74) | 0.488 | MCP-1 | 2.05 (1.83, 2.37) | 2.05 (1.83, 2.82) | 0.726 |
IL-8 | 19.37 (2.26, 82.16) | 8.76 (2.23, 49.89) | 0.606 | MCP-3 | 1.22 (0.99, 1.53) | 1.27 (0.99, 1.59) | 0.990 |
*IL-9 | 34.58 ± 12.42 | 43.42 ± 20.74 | 0.037 | β-NGF | 1.77 ± 0.29 | 1.77 ± 0.23 | 0.946 |
IL-10 | 3.09 (2.86, 3.32) | 3.09 (2.86, 3.37) | 0.588 | *RANTES | 303.17 ± 266.21 | 670.64 ± 511.61 | 0.001 |
IL-12(p40) | 26.22 (22.45, 30.84) | 23.90 (20.11, 33.14) | 0.416 | SDF-1α | 60.77 (42.57, 107.66) | 63.53 (46.01 ,112.12) | 0.556 |
IL-12(p70) | 2.14 (2.06, 2.14) | 2.08 (2.01, 2.14) | 0.117 | PDGF-BB | 50.17 (27.83, 236.28) | 97.99 (39.05, 447.97) | 0.262 |
IL-13 | 1.08 (0.92, 1.12) | 1.00 (0.92, 1.24) | 0.650 | GRO-α | 115.22 (105.73, 133.88) | 117.51 (108.15, 134.90) | 0.457 |
IL-16 | 9.01 (6.93, 12.53) | 10.13 (7.31, 21.04) | 0.394 | *HGF | 233.76 ± 192.31 | 360.28 ± 292.57 | 0.039 |
IL-17 | 3.51 (3.10, 4.29) | 3.69 (3.10, 4.44) | 0.681 | IP-10 | 15.23 (10.33, 23.44) | 15.62 (11.06, 28.91) | 0.447 |
IL-18 | 2.00 (1.73, 2.56) | 2.43 (1.82, 2.97) | 0.152 | CTACK | 3.63 (3.28, 3.99) | 3.55 (3.28, 3.99) | 0.569 |
IFN-α2 | 5.12 (4.50, 5.30) | 4.74 (4.16, 5.66) | 0.543 | MIF | 22.74 (12.12, 38.11) | 32.20 (15.86, 88.95) | 0.080 |
IFN-γ | 1.47 (1.28, 1.62) | 1.56 (1.35, 1.74) | 0.137 | MIG | 12.59 (8.69, 28.07) | 15.91 (9.46, 31.45) | 0.387 |
TNF-α | 7.43 ± 1.71 | 7.12 ± 1.35 | 0.419 | SCGF-β | 3642.80 (1083.20, 9553.74) | 2012.10 (1009.60, 7772.50) | 0.528 |
* TNF-β | 24.9 ± 9.15 | 31.79 ± 15.33 | 0.029 | TRAIL | 1.96 (1.56, 3.01) | 2.13 (1.67, 2.94) | 0.361 |