Fig. 3

Phosphoproteomic analysis of hiPSC-CMs deficient in PINK1. A Number of phosphosites, phosphopeptides, and phosphoproteins. B PCA of phosphosites identified by phosphoproteomic in hiPSC-CMs lacking PINK1. C Hierarchical clustering heatmap of phosphosites identified by phosphoproteomic in hiPSC-CMs lacking PINK1. D Percentage of significantly differentially expressed phosphosites (P < 0.05). E Volcano map of significantly differentially expressed phosphosites in hiPSC-CMs lacking PINK1. F Hierarchical clustering heatmap of significantly differentially expressed phosphosites in hiPSC-CMs lacking PINK1. G–I GO enrichment analysis of significantly differentially expressed phosphoproteins in hiPSC-CMs lacking PINK1