Fig. 7
The effect of overexpression of IFI6 in MSCs on the gene expression profile of leukemia cells. A The distributions of gene expression in RS4;11 cells co-cultured with MSCs-EV and MSCs-LV-IFI6 for 72 h based on log10(FPKM), (n = 3). B The gene expression density of RS4;11 cells co-cultured with MSCs-EV and MSCs-LV-IFI6. C Histogram of differential expressed genes in RS4;11 cells co-cultured with MSCs-LV-IFI6 compared to RS4;11 cells co-cultured with MSCs-EV group based on -log10 (P value). D and E The volcano plots and heatmap (Top 100) of differential gene expression in RS4;11 cells co-cultured with MSCs-LV-IFI6 compared to RS4;11 cells co-cultured with MSCs-EV group based on -log10 (P value). F and G GO Enrichment doughnut-Biological Process (F) and KEGG Enrichment BarPlot (G) of differentially expressed genes in RS4;11 cells co-cultured with MSCs-LV-IFI6 compared to RS4;11 cells co-cultured with MSCs-EV. H Over-Representation Analysis (ORA) for the GO Slim summary of differentially expressed genes in RS4;11 cells co-cultured with MSCs-LV-IFI6 compared to RS4;11 cells co-cultured with MSCs-EV (Of the 210 differential genes included, 209 user IDs were identified. Among them, 114 user IDs were unambiguously mapped to 114 unique entrezgene IDs. And the GO Slim summary were based upon the 114 unique entrezgene IDs)