Fig. 6

A Tumor mutation burden (TMB) among the three IFN-λ subgroups. B–C Boxplots showing the comparisons of mutation frequencies of B SNV and C every mutation type classified by effects between the BSE and NSE groups. D The mutational landscapes of the BSE and NSE groups. E Forest plot displays the top 9 most significantly differentially mutated genes between the BSE and NSE groups. F Effects of IFN-λ expression and TP53 mutation status on OS in the training set. G Kaplan–Meier curves show the independent relevance between overall survival time and risk scores in the training (left) and validation set (right). H Methylation expression levels of IFNL 2 and IFNL 3 among the three IFN-λ expression subgroups. I The distribution of DMPs in BSE and NSE groups was exhibited by heatmap. J The left plot illustrates the relationships between expression change and DNA methylation level. The nodes in red represent the DEGs with log2FC of FPKM > 1.5 and Δbeta > 0.15. The right plot illustrates the heatmap of these DEGs. K The results of GO biological process enrichment analyses on DMP-associated genes