Fig. 5

A Immune and stromal cell infiltration levels between BSE and NSE groups (left) and differences in immune and stromal cell infiltration between BSE and NSE groups (right). B Correlation between each infiltration cell type and IFN-λ expression. C Distribution of expression changes in immune cells. D Boxplots of resistance-associated ISGs (ISG.RS) and IFNG-related ISGs (IFNG.GS) expression in BSE and NSE groups. E Expression heatmap of T cell dysfunction and T cell inflammation related-genes. F Immune checkpoint tumor cell (upper) and immune checkpoint T cell (lower) corresponding gene normalized expression in three IFN-λ expression subgroups. G Heatmap showing the expression of major histocompatibility complex class I (MHC-I), MHC-II, and mesenchymal-like (MES-like) related genes in three IFN-λ expression subgroups. H The proportion of patients with response to PD-L1 blockade immunotherapy in NSE and BSE/OSE groups. SD stable disease; PD progressive disease; CR complete response; PR partial response