Fig. 3
A The ligand-receptor network of IFN-λ-related gene. B Analysis of the t-SNE of the pan-cancer samples based on the expression of ligand-receptor genes, the NSE group patients, pink; the BSE group patients, blue. C Interaction of the enriched pathways. The size represents the number of genes, and the color represents the p-value. D KM survival curve for classifying the high and low risks of TCGA validation set samples was constructed by IFN-λ-related ligand receptor genes as features. E The ROC curve of the model. F The PPI network of IFN-λ-related gene. G KM survival curve for classifying the high and low risks of TCGA validation set samples was constructed by IFN-λ- related proteins genes as features. H KM survival curves of OS of patients in the low- and high-risk groups in GSE42568 cohort. I The ROC curve of the model. J Pictorial representation of IFN-λ regulation combined our findings. K Diagram of the transcription factors (STAT1, STAT2, STAT3) and the target gene networks. L KM survival curve for classifying the high and low risks of TCGA validation set samples was constructed by IFN-λ- related target gene as features. M The IFN-λ associated genes normalized expression in the three groups