Fig. 1

A Bar plots showing proportions of IFNL2, IFNL3, CGB3 and CGB5 specific expression in cancer and normal samples. C, cancer, N, normal. B Consistent clustering result by the K-means method to cluster the TCGA training set into four groups. C Heatmap showed the expression of the specific-genes in four groups. D Kaplan–Meier curves of OS among the four patient groups in the training cohort. E The histogram showing proportions of the gene specific expression incancer and normal samples. -, no-expression, + , expression F Survival analysis for subgroups patients stratified by GSE using the Kaplan–Meier curves. G Forest plot of multivariate Cox regression analysis for GSE subgroups related to prognosis. H–I Kaplan–Meier estimates of overall survival for the IFN_exp and the rest group in the training H and validation I cohort