Fig. 7

Inhibiting CX3CL1 alleviates spinal damage, intestinal inflammation, and M1 macrophage polarization in AS-model mice. A Thickness of limbs in mice; B safranin O-Fast Green staining of intervertebral discs in the spine; C MicroCT of the spine; D bone density values; E intestinal length; F HE staining of intestinal tissue; G intestinal permeability test; H, I western blot detection of TNF-α, IL-17, and iNOS expression in mouse intestines; J immunofluorescence detection of CX3CL1 and iNOS expression in mice intestines. n = 3, data are represented as mean ± SD, ^∗p < 0.05 vs. Control, ^∗∗p < 0.01 vs. Control, ^∗∗*p < 0.001 vs. Control