Table 2 The relationship between SNPs of XRCC1–6 and tumour

XRCC1

G>C

c.1517

Increased risk of hepatocellular carcinoma development

[147]

Arg399Gln

exon 10

Genetic biomarker of squamous cell carcinoma of the head and neck

[148]

Arg399Gln

exon 10

Increased childhood risk of acute lymphoblastic leukemia

[149]

G>A

c. 1196

Influence of colorectal cancer on the clinical outcomes of patients

[150]

XRCC2

R188H

rs3218536

Influence breast cancer risk and survival

[151]

C>T

rs718282

Increased the cancer risk of endometrial cancer

[152]

XRCC3

Thr241Met

rs861539

Associated with the survival of glioblastoma multiforme patients

[153]

A>G

rs1799796

Increased risk of prostate cancer

[154]

A>G

rs1799794

Modulates the risk of head and neck cancer

[155]

XRCC4

G>T

c.1394

Associated with breast cancer development

[65]

S110P

rs79561451

Influence the susceptibility of individuals to breast cancer

[156]

A>G

rs1805377

Genetic markers of hepatocellular carcinoma

[157]

XRCC5

G>A

rs207906

Increased susceptibility to leukaemia

[158]

XRCC6

C>G

c.-1310

Associated with breast cancer risk and oestrogen exposure

[159]