Fig. 7

Schematic diagram of the mechanism of STING involved in RILI injury. A In RILI, the lung was damaged by radiation and emitted fragments of broken DNA. These fragments stimulated macrophage STING signaling activity. STING signaling activation promoted paracrine release of cytokines, such as CCL2, leading to the recruitment and polarization of macrophages in the lung, which eventually resulted in the development of RILI. B Deficiency in STING signaling, as well as the introduction of CCL2 inhibitor Bindarit, decreases the recruitment and polarization of macrophages, thereby alleviating RILI