Fig. 6

STING expression, dynamic changes of CCL2 and RILI in patients. A Representative images of STING expression in the normal lung tissue specimens by IHC. Scale bars: 100 µm (20 × magnification). B Representative CT scans from patients with various degrees of RILI. C The correlation between the severity of RILI and STING expression in the pre-radiotherapy lung tissues. D The correlation between fold changes of circulating CCL2 after radiotherapy and STING expression in the pre-radiotherapy lung tissues. E The correlation between the severity of RILI and fold changes of circulating CCL2 after radiotherapy. Error bars represent mean ± SD. Statistical significance was calculated using one way ANOVA by Tukey’s multiple comparisons test. *P < 0.05; **P < 0.01; ***P < 0.001