Fig. 4

Changes of cytokines in RILI mice model. A The heatmap showing the cytokines mRNA levels by RNAseq. B–F The IL-2, IL-4, IL-10, IL-13 and CCL2 concentration in Bronchoalveolar lavage fluid 24, and 48 h after and 1, 4, 8, and 16 weeks after irradiation in RILI mice model by ELISA. G–K The IL-2, IL-4, IL-10, IL-13 and CCL2 concentration in serum 24, and 48 h after and 1, 4, 8, and 16 weeks after irradiation in RILI mice model by ELISA. L The correlation between the CCL2 concentration in Bronchoalveolar lavage fluid and the activity of the STING signaling pathway. M The correlation between the CCL2 concentration in Bronchoalveolar lavage fluid and the population of macrophages. N The correlation between the CCL2 concentration in Bronchoalveolar lavage fluid and the macrophages M1 polarization percentage. Error bars represent mean ± SD. Statistical analyses were performed using two-tailed Students t-test or one-way ANOVA if more than two groups. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001