Fig. 1

Thoracic radiation activated STING signaling and promoted RILI in mice. A A schematic diagram depicting the mice model of RILI is shown in A. B The proteins levels of STING signaling pathway in the lung tissues of RILI mice model. C Lung IFN-alpha and IFN-beta mRNA levels on 0 h, 24 h, 48 h and 1 week after irradiation in the RILI mice model (n = 3). D The phosphorylation levels of STING on 0 h, 24 h, 48 h and 1 week after irradiation in the lung tissues of RILI mice model(n = 6). E The H&E staining of lung tissues on 0, 4, 8, 12, 24 weeks after irradiation in RILI mice model(n = 6). Scale bars: 100 µm (20 × magnification). F The Masson`s trichrome staining of lung tissues on 0, 4, 8, 12, 24 weeks after irradiation in RILI mice model (n = 6). Scale bars: 100 µm (20 × magnification). G The correlation between the severity of RILI and the activity of the STING signaling pathway. Error bars represent mean ± SD. Statistical analyses were performed using two-tailed Students t-test or one-way ANOVA if more than two groups. ***P < 0.001; ****P < 0.0001