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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: Sildenafil, a phosphodiesterase-5 inhibitor, stimulates angiogenesis and bone regeneration in an atrophic non-union model in mice

Fig. 8

a Western blots of CYR61 expression within the callus tissue of controls and sildenafil-treated mice at 2, 5 and 10 weeks after surgery. b Expression of CYR61 (pixel intensity ×104) within the callus tissue of controls (white bars, n = 3) and sildenafil-treated mice (black bars, n = 3) at 2, 5 and 10 weeks after surgery. c Western blots of VEGF expression within the callus tissue of controls and sildenafil-treated mice at 2, 5 and 10 weeks after surgery. d Expression of VEGF (pixel intensity ×104) within the callus tissue of controls (white bars, n = 3) and sildenafil-treated mice (black bars, n = 3) at 2, 5 and 10 weeks after surgery. e Western blots of HO-1 expression within the callus tissue of controls and sildenafil-treated mice at 2, 5 and 10 weeks after surgery. f Expression of HO-1 (pixel intensity ×104) within the callus tissue of controls (white bars, n = 3) and sildenafil-treated mice (black bars, n = 3) at 2, 5 and 10 weeks after surgery. g Western blots of PCNA expression within the callus tissue of controls and sildenafil-treated mice at 2, 5 and 10 weeks after surgery. h Expression of PCNA (pixel intensity ×104) within the callus tissue of controls (white bars, n = 3) and sildenafil-treated mice (black bars, n = 3) at 2, 5 and 10 weeks after surgery. Mean ± SEM; *p < 0.05 vs. control

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