Table 2 Local tumor control of tumor models. a) Tumor control rate (TCR) until day 120–180 after RCTx with 30 fractions in 6 weeks, weekly cisplatin and nimorazole or carrier. b) Hazard ratios (HR) and corresponding 95% confidence intervals of RCTx + nimorazole vs RCTx + carrier and RCTx + nimorazole (after 10fx) vs RCTx + carrier, p values after (p adj) correcting for multiple testing

54

85.0

[70.7, 100.0]

85.4

[71.4, 100.0]

52.8

[35.7, 77.9]

90

62.3

[50.2, 77.3]

48.0

[35.5, 64.8]

32.4

[21.4, 49.1]

93

54.2

[37.5, 78.3]

38.5

[23.7, 62.5]

29.0

[15.0, 55.9]

42

89.0

[80.2, 98.9]

81.4

[71.6, 92.5]

72.6

[61.3, 86.0]

36

60.2

[48.3, 75.0]

50.8

[39.0, 66.3]

52.0

[39.8, 68.0]

39

76.5

[63.4, 92.4]

75.5

[62.2, 91.5]

80.2

[69.3, 92.8]

30

17.5

[9.4, 32.6]

31.0

[19.3, 50.0]

32.3

[19.9, 52.4]

0.24

[0.07, 0.88]

*0.043

0.22

[0.06, 0.81]

*0.043

0.37

[0.21, 0.66]

*0.002

0.54

[0.32, 0.91]

*0.022

0.44

[0.20, 0.96]

0.074

0.69

[0.34, 1.41]

0.311

0.32

[0.11, 0.88]

0.052

0.63

[0.28, 1.43]

0.270

0.69

[0.38, 1.26]

0.376

0.91

[0.52, 1.60]

0.752

1.22

[0.47, 3.16]

0.872

1.23

[0.49, 3.10]

0.872

1.58

[0.97, 2.59]

0.119

1.17

[0.69, 1.98]

0.565