Fig. 4

Validation on retrospective HNSCC cohort of the DKTK-ROG that received primary RCTx. A Patients are split into two groups according to differentially expressed genes (DEG). Patients with an overall lower expression are grouped into”low”, patients with an overall higher expression are grouped into”high” using k-means clustering. Data is z-transformed, error bars indicate standard error of the mean. B, C Kaplan-Meier estimates on loco-regional control and distant metastases, for patients grouped into low and high gene expression. P values correspond to log-rank tests.