Fig. 3

Results of RNA-Profiling. A Results of differential gene expression (DGE) analysis of responding (FaDu, SAS) and non-responding (UT45, CAL33, SAT) models to nimorazole in RCTx + nimorazole treated samples. The box plots displayed adhere to the Tukey style (see Methods). See also Additional file 1: Table S3. B Comparisons considered in DGE (e.g., FaDu vs SAT, FaDu vs CAL33, et cetera). UT5 and UT8, showing only low response to nimorazole according to TCR, have been excluded from this consideration. C Heatmap of differentially expressed genes (DEG) in all treatment groups. Genes shown with grey labels are only differentially expressed in RCTx + nimorazole treated samples but not in untreated samples. UT5 and UT8, not part of DEG analysis (left, grayed), illustrate a different pattern compared to responders and non-responders to nimorazole for the genes shown. Data is z-transformed, yellow: high expression, grey: low expression