Fig. 2

Upregulated expression of miR-125a-5p targets ETS-1, IFN-γ, and STAT3 in psoriatic CD4⁺T cells. a, b ETS-1, IFN-γ, and STAT3 were predicted to be targeted by miR-125a-5p using TargetScan (a) and mirDIP (b). c ETS-1 expression in peripheral CD4⁺ T cells of psoriasis patients and normal healthy controls was analyzed by qRT-PCR (n = 10 per group, p < 0.01). d IFN-γ expression in peripheral CD4⁺ T cells of psoriasis patients and normal healthy controls was analyzed by qRT-PCR (n = 10 per group, p < 0.001). e STAT3 expression in peripheral CD4⁺ T cells of psoriasis patients and normal healthy controls was analyzed by qRT-PCR (n = 10 per group, p < 0.001). Data are representative of three independent experiments (mean ± SEM). *P < 0.05, **P < 0.01, ***P < 0.001. Two-tailed unpaired Student’s t-test (c, d and e). miR microRNA; STAT3 Signal transducer and activator of transcription 3; ETS-1 E26 transformation specific-1; IFN-γ Interferon-γ; qRT-PCR quantitative real-time PCR