Fig. 1

miR-125a-5p expression is reduced in CD4⁺T cells, linked to Th17/Treg balance and psoriasis severity. a miR125a-5p expression in peripheral CD4⁺ T cells of psoriatic patients and normal healthy controls were analyzed by qRT-PCR (n = 10 per group, p < 0.001). b Negative correlation of human miR-125a-5p expression in psoriatic CD4⁺ T cells with PASI scores (n = 10, p < 0.001). c Negative correlation of miR-125a-5p expression in psoriatic CD4⁺ T cells with the proportion of Th17 cells in peripheral CD4⁺ T cells of psoriasis patients (n = 10, p < 0.001). d Positive correlation of miR-125a-5p expression in psoriatic CD4⁺ T cells with the proportion of Treg cells in peripheral CD4⁺ T cells of psoriasis patients (n = 10, p < 0.001). Data are representative of three independent experiments (mean ± SEM). *P < 0.05, **P < 0.01, ***P < 0.001. Two-tailed unpaired Student’s t-test a, Spearman’s r test b, c and d. miR microRNA; qRT-PCR quantitative real-time PCR; PASI psoriasis area and severity index; Th17, T helper cell 17; Treg regulatory T cel