Fig. 6

JMJD6 promotes radioresistance of LCSCs by regulating the HOTAIR-LSD1-ERK2 axis. A The diameter of xenograft tumors of nude mice in response to JMJD6 silencing alone or in combination with ERK2 (MAPK1) overexpression (n = 6). B The weight of xenografted tumors in nude mice in response to JMJD6 silencing alone or in combination with ERK2 (MAPK1) overexpression (n = 6). C The expression of HOTAIR in xenografted tumor tissues of nude mice in response to JMJD6 silencing alone or in combination with ERK2 (MAPK1) overexpression determined by RT-qPCR, normalized to GAPDH (n = 6). D The ERK2 (MAPK1) positive cells in xenograft tumor tissues of nude mice in response to JMJD6 silencing alone or in combination with ERK2 (MAPK1) overexpression, as detected by immunohistochemistry (n = 6). E Cell proliferation in xenografted tumors of mice in response to JMJD6 silencing alone or in combination with ERK2 (MAPK1) overexpression, as detected by Ki-67 staining (n = 6). F Cell apoptosis in xenografted tumors of mice in response to JMJD6 silencing alone or in combination with ERK2 (MAPK1) overexpression, as detected by TUNEL staining (n = 6). *p < 0.05 compared with shCtl + oe-NC-treated mice. #p < 0.05 compared with shJMJD6 + oe-NC-treated mice. Measurement data were represented as mean ± standard deviation. The data comparison between multiple groups was performed by one-way ANOVA with Tukey’s post-hoc test