Fig. 6

Spatial distribution and heatmaps of OTOP2, FGFR2 and MMP11. a The virtually stained H&E images of the samples from non-relapsed (patient 1–5) and relapsed patients (patient 6–10). Expression and the spatial distribution of b OTOP2, c FGFR2 and d MMP11 and heatmaps of e OTOP2, f FGFR2 and g MMP11. Total counts of each transcript are depicted in each image and size bar is the same for all images. The heatmaps visualize tumour heterogeneity, whereby each plot is normalised to its own maximum density value. The heat scale colour bar in e, patient 10 is the same for all heatmaps