Fig. 3

Examples of spatial distributions of 5 out of 176 genes in neoplastic and non-neoplastic tissue. a The virtually stained H&E images of the samples from non-relapsed (patient 1–5) and relapsed patients (patient 6–10). b Expression and the spatial distribution of MET, a gene of the tumour gene signature that was used for the creation of the neoplastic tissue compartment. c Exemplified expression and the spatial distribution of MUC2, a gene expressed in non-neoplastic epithelial- and cancer cells. d Exemplified expression and the spatial distribution FABP1, a high expressed gene in colonic tissue. e Expression of OLFM4, a gene associated to inflamed colonic epithelium and antiapoptotic features. f Expression of COL1A, a gene relevant in forming collagen and found in most connective tissues. Total counts of each transcript are depicted in each image and size bar is the same for all images