COVPRIG robustly predicts the overall survival of IDH wild-type glioblastoma and highlights METTL1+ neural-progenitor-like tumor cell in driving unfavorable outcome

Table 1 Systemic review of the prognostic model for IDH wildtype GBM

No	PMID	Method	Description	Ethnicity	Validation type	Data source		Sample size			Performance in train set		Performance in validation set
No	PMID	Method	Description	Ethnicity	Validation type	Train	Validation	Train	Validation	Total	AUC	C-index	AUC	C-index
1		Cox	mRNA and age-based model	Tans-ethnic	External	TCGA_RNAseq, TCGA_microarray	CGGA693 GSE16011	143 + 372	190 + 95	800	AUC_18-month = 0.79	0.62	AUC_18-month = 0.70	0.60
2	34830935	Cox	neutrophil-to-lymphocyte ratio			Local		85		85	AUC_NLR = 0.58AUC_dNLR = 0.62
3	35610333	SVM, Cox	Multi-omics data		Internal	Local	Local	404	112	516	0.75	0.75	0.63
4	31632497	Cox	mRNA-based model	Tans-ethnic	Internal, External	TCGA_RNA-seq	TCGA_microarray, GEO, CGGA, Local	195	529, 54, 144, 178	905	0.82
5	31921684	Cox, LASSO	mRNA-based model	Tans-ethnic	External	CGGA	TCGA_RNAseq TCGA_microarry	105	139 386	630	AUC_12-month = 0.78		AUC_12-month = 0.74
6	32851059	Cox	Lnc-RNA-based model	Tans-ethnic	External	TCGA CGGA325	CGGA693				AUC_12-month = 0.74 AUC_36-month = 0.87		AUC_12-month = 0.55 AUC_36-month = 0.73
7	31167648	Cox	MGMT promoter methylation			Local		111		111	0.77
8	35153659	LASSO Cox	MRI and clinical features	Tans-ethnic	Internal	TCGA Local		100	42	142		0.84		0.80

ISSN: 1479-5876