Table 1 Banff classification of acute rejection in skin-containing allografts
From: Methods of ex vivo analysis of tissue status in vascularized composite allografts
Grade 0 | Â | No or rare inflammatory infiltrates |
Grade I | Mild | Mild perivascular infiltration. No involvement of the overlying epidermis |
Grade II | Moderate | Moderate-to-severe perivascular inflammation with or without mild epidermal and/or adnexal involvement (limited to spongiosis and exocytosis. No epidermal dyskeratosis or apoptosis |
Grade III | Severe | Dense inflammation and epidermal involvement with epithelial apoptosis, dyskeratosis, and/or keratinolysis |
Grade IV | Necrotizing acute rejection | Frank necrosis of epidermal or other skin structures |